Anti-adhesive Effect of Poloxamer/Alginate/CaCl2 Mixture in the Rat Model

PURPOSE: The occurrence of post-surgical adhesion is still a major cause of postoperative morbidity due to the lack of satisfactory treatment or prophylaxis. Several adhesion barriers have been developed in the form of solutions or membrane in an attempt to solve these problems. However both types of tissue barriers have some limitations in their practical applications. In order to overcome these problems, a temperature-sensitive Poloxamer/Alginate/CaCl2 mixture was prepared as an adhesion barrier. With this material, toxicity, inflammation and the adhesion prevention effect was evaluated in an animal model. METHODS: The sol-gel transition behavior was measured using a viscometer. An in vitro gel stability test and an in vivo degradation test was performed. The anti-adhesion effect was evaluated using a cecal-abdominal wall abrasion model. The denuded cecum was coated with Poloxamer/ Alginate/CaCl2 mixture, GUARDIX-SL (positive control group) or neither (negative control group) and apposed to the abdominal wall (each n=14). One week after surgery, the level of adhesion was graded from zero to three using a whole-number system. RESULTS: The LCST of the poloxamer/sodium alginate mixture was 25 degrees C. The gel stability of Poloxamer was improved by adding mild cross-linked sodium Alginate/CaCl2 mixture. The adhesion grade and area were significantly lower in the experimental group than in the control. CONCLUSION: The anti-adhesive effect of the Poloxamer/Alginate/CaCl2 mixture was comparable to the previously- developed solution type barrier and all the materials had degraded within 21 days. From these results, Poloxamer/ Alginate/CaCl2 mixture is a good candidate for use as a coatable or injectable tissue adhesion barrier.

A Management System of Data for Department of Diagnostic Radiology and Patients Using the Personal Computer

PURPOSE: With the use of personal computers generalized, departmental society leveled computerization isgoing on in some other departments. So we tried to develop a program having a simple user interface, various retrieval functions and, analytic & statistic process system to effectively help patient care suitable for works concerned with department of diagnostic radiology and works of department. MATERIALS AND METHODS: This programdeals with such target works as department of diagnostic radiology and some works to need a lot of book keeping. Itis deviced to operate with windows (Microsoft, America), and central processing unit(486DX-2), memory unit(8Mbyte). As a developmental tool, Foxpro 2.6 for windows R(Microsoft, America). RESULTS: This Program can be easily accessed even by staffs poor at computer and it can make many books recording various check-ups and operations unnecessary, which were difficult to keep. Besides, it can keep data as a unified form, and so it provides patient care and other works with convenience and helps applying those stored data scientific research. CONCLUSION: The above result shows that works of department can be effectively controlled by analyzing or printing various check-up and operation done by department of diagnostic radiology.